Ever since she can remember, Saiki Misaki has had the ability to talk to ghosts. She works as a special consultant for the city's secret division that deals with supernatural cases. She also works as a dominatrix at an S&M club, where she has gained a cult following for her extraordinary ability to tame men's twisted desires. These special talents, however, forbid her to lead an ordinary life. Every day she has to deal with overzealous fans/stalkers, and worse, lost spirits in desperate need of help.

Misaki Saiki investigates a haunting in an apartment where a mother and daughter died under suspicious circumstances. Working with Souichiro from the Social Work Division, she exorcises the spirits while establishing her unique role as a dominatrix who communicates with ghosts.

Ai, a high school student who can now see ghosts, joins Misaki in investigating mysterious phenomena in Nakano. Their search leads them to a house tied to Misaki's childhood memories, where they confront trapped spirits and protect Ai from danger.

After finding evidence linking a murder to the Matsuda kidnapping case, Misaki and Souichiro hunt down Koga, the man responsible for killing a young girl. The investigation escalates when Ai's safety is threatened, forcing Misaki to face Koga and his associates with help from her demonic familiar.

The Matsuda kidnapping mystery reaches its conclusion as Misaki encounters ghost children on a mountain road. Detective Yamazaki reveals disturbing truths about Ichinose's past, helping the remaining spirits find closure after 12 years of unresolved tragedy.