Melissa De Sousa is an actress best known for her role as Shelby in the 1999 romantic comedy-drama film The Best Man, its 2013 sequel The Best Man Holiday, Gabriella Jimenez in BET's Reed Between the Lines, and Ana Lopez in Black Lightning.
2026A Proud Family WizmasMovieas Sunset Boulevardez (voice)
2025Operation: AuntiesMovieas Carol
2022The Best Man: The Final ChaptersTV showas Shelby · 8 episodes2022Bel-AirTV showas Steph · 1 episodes2019The Kelly Clarkson ShowTV showas Self · 1 episodes2019On Becoming a God in Central FloridaTV showas Mirta Herrera · 5 episodes
2018Ladies of the LawTV showas Tina · 6 episodes2018Black LightningTV showas Chief Ana Lopez · 8 episodes
2015SupermodelMovieas Det. Lacey
2015Divas!Movieas Angie
2014CruMovieas Michelle Hughes2013The Best Man HolidayMovieas Shelby2012ElementaryTV showas Luz Horowitz · 1 episodes
2011Reed Between the LinesTV showas Gabriella Jimenez · 25 episodes
2011Single LadiesTV showas Austin Aguilera · 6 episodes
2011AshesMovieas Camille2011ShamelessTV showas Tina · 1 episodes2009CastleTV showas Liz Penn · 1 episodes
2008A Good Man Is Hard to FindMovieas Monica2007Bats: Human HarvestMovieas O'Neal
2007ConstellationMovieas Lucy Boxer2006The Ron Clark StoryMovieas Marissa Vega
2006Saturday Night LifeMovieas Darlene Maye2005Ghost WhispererTV showas Christine Nelson · 1 episodes2005Criminal MindsTV showas Adele McCord · 1 episodes2003Laurel CanyonMovieas Claudia
200130 Years to LifeMovie
2001One on OneTV showas Natalie · 12 episodes2000Miss CongenialityMovieas Karen "New York"
2000The $treetTV showas Donna Pasqua · 12 episodes2000LockdownMovieas Krista1999The Best ManMovieas Shelby
1998RideMovieas Leta
1998DamonTV showas Stacy Phillips · 13 episodes1996MoeshaTV showas Jennifer · 1 episodes1995The Wayans Bros.TV showas Charmaine · 1 episodes1994ERTV showas Estella · 1 episodes
1994Valley of the DollsTV showas Neely O'Hara · 1 episodes1993Living SingleTV showas Carmen · as Lisa · 1 episodes